Statins and sepsis
نویسندگان
چکیده
منابع مشابه
REVIEWARTICLES Statins and sepsis
Severe sepsis and septic shock is common and frequently fatal. Over the last few years, the primary treatments demonstrated to improve outcome from several major clinical trials have finally emerged. However, translating these recent therapeutic advances to routine clinical practice has proven controversial, and new approaches of additional strategies are continued to be developed. Given their ...
متن کاملStatins and sepsis
1 Angle PJ, Halpern SH, Leighton BL, Szalai JP, Gnanendran K, Kronberg JE. A randomized controlled trial examining the effect of naproxen on analgesia during the second day after cesarean delivery. Anesth Analg 2002; 95: 741–5 2 American Academy of Pediatrics Committee on Drugs. The transfer of drugs and other chemicals into human milk. Pediatrics 1994; 93: 137–50 3 Fenton C, Keating GM, Wagsta...
متن کاملStatins and Sepsis
tional Ang-2 allele are protected from lung injury and vascular leak (7). Serum from both patients with sepsis (7) and those with ALI (6) disrupts endothelial barrier function, via a mechanism that is blocked via Ang-2 blockade (6, 7). These deleterious effects of Ang-2 on the endothelial barrier function appear to be mediated via a conditional antagonism of the tyrosine kinase receptor Tie 2, ...
متن کاملStatins and Sepsis Literature Review
Recent data suggest that, in addition to improving dyslipidemia, statin may reduce the risk of infections and infectionrelated complications. The aim of this study is to make a review of the literature about the effects of statins on clinically relevant outcomes of patients admitted to the hospital and having an infection and/or sepsis, principally in terms of intensive care unit admissions and...
متن کاملStatins, inflammation, and sepsis: hypothesis.
Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humoral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against seps...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2008
ISSN: 0007-0912
DOI: 10.1093/bja/aen114